45) Yu, H.-C.; Islam, S. M.; Mankad, N. P. “Cooperative heterobimetallic substrate activation enhances catalytic activity and amplifies regioselectivity in 1,4-hydroboration of pyridines.” ACS Catal. 2020, 10, 3670-3675.

44) Rathnayaka, S. C.; Islam, S. M.; DiMucci, I. M.; MacMillan, S. N.; Lancaster, K. M.; Mankad, N. P. “Probing the Electronic and Mechanistic Roles of the µ4-Sulfur Atom in a Synthetic CuZ Model System.” Chem. Sci. 202011, 3441-3447. *ChemSci Pick of the Week *HOT Article
Get RSCIS_43_3_infographic_Mar_11_2020_landscape

43) Cheng, L.-J.; Mankad, N. P. “Cu-Catalyzed Carbonylative Silylation of Alkyl Halides: Efficient Access to Acylsilanes.” J. Am. Chem. Soc. 2020142, 80-84.
*Synfacts highlight by M. Lautens & R. Ross

42) Zhao, S.; Mankad, N. P. “Synergistic Copper-Catalyzed Reductive Aminocarbonylation of Alkyl Iodides with Nitroarenes.” Org. Lett. 201921, 10106-10110.

41) Leon, N. J.; Yu, H.-C.; Mazzacano, T. J.; Mankad, N. P. “Pursuit of C–H Borylation Reactions with Non-Precious Heterobimetallic Catalysts: Hypothesis-Driven Variations on a Design Theme.” Synlett 202031, 125-132. *Account

40) Hsu, C.-W.; Rathnayaka, S. C.; Islam, S. M.; MacMillan, S. N.; Mankad, N. P. “N2O Reductase Activity of a [Cu4S] Cluster in the 4CuI Redox State Modulated by Hydrogen Bond Donors and Proton Relays in the Secondary Coordination Sphere.” Angew. Chem., Int. Ed. 202059, 627-631.

39) Zhao, S.; Mankad, N. P. “Metal-Catalysed Radical Carbonylation Reactions.Catal. Sci. Tech. 2019, 9, 3603-3613. *Mini-review

38) Zhang, Y.; Karunananda, M. K.; Yu, H.-C.; Clark, K. J.; Williams, W.; Mankad, N. P.; Ess, D. H. “Dynamically Bifurcating Hydride Transfer Mechanism and Origin of Inverse Isotope Effect for Heterodinuclear AgRu-Catalyzed Alkyne Semi-Hydrogenation.” ACS Catal. 2019, 9, 2657-2663.

37) Cheng, L.-J.; Mankad, N. P. “Heterobimetallic Control of Regioselectivity in Alkyne Hydrostannylation: Divergent Syntheses of α- and (E)-β-Vinylstannanes via Cooperative Sn-H Bond Activation.” J. Am. Chem. Soc. 2019, 141, 3710-3716.
*Highlighted in Organic Chemistry Portal

36) Mankad, N. P. “Catalysis with Multinuclear Complexes.” In Non-Noble Metal Catalysis: Molecular Approaches and Reactions; Klein Gebbnik, R. J. M..; Moret, M.-E., Eds.; Wiley-VCH 2019; pp. 49-68. ISBN: 978-3-527-34061-3. [book link]

35) Leon, N. J.; Yu, H.-C.; Mazzacano, T. J.; Mankad, N. P. “Mixed Phosphine/Carbonyl Derivatives of Heterobimetallic Copper-Iron and Copper-Tungsten Catalysts.” Polyhedron 2019, 157, 116-123. *Special Issue for Bill Jones 65th Birthday.

34) Rathnayaka, S. C.; Lindeman, S. V.; Mankad, N. P. “Multinuclear Cu(I) Clusters Featuring a New Triply Bridging Coordination Mode of Phosphaamidinate Ligands.” Inorg. Chem. 2018, 57, 9439-9445.

33) Cheng, L.-J.; Mankad, N. P. “Cu-Catalyzed Borocarbonylative Coupling of Internal Alkynes with Unactivated Alkyl Halides: Modular Synthesis of Tetrasubstituted β-Borylenones.” Angew. Chem., Int. Ed. 2018, 57, 10328-10332.

32) Zhao, S.; Mankad, N. P. “Cu-catalyzed Hydroxymethylation of Unactivated Alkyl Iodides with CO to Provide One Carbon Extended Alcohols.” Angew. Chem., Int. Ed. 2018, 57, 5867-5870.

31) Mankad, N. P. “Diverse Bimetallic Mechanisms Emerging from Transition Metal Lewis Acid/Base Pairs: Development of Co-catalysis with Metal Carbenes and Metal Carbonyl Anions.” Chem. Commun. 2018, 54, 1291-1302. *Feature Article.

30) Bagherzadeh, S.; Mankad, N. P. “Oxidation of a [Cu2S] Complex by N2O and CO2: Insights into a Role of Tetranuclearity in the CuZ Site of Nitrous Oxide Reductase.” Chem. Commun. 2018, 54, 1097-1100.

29) Cheng, L.-J.; Islam, S. M.; Mankad, N. P. “Synthesis of Allylic Alcohols via Cu-Catalyzed Hydrocarbonylative Coupling of Alkynes with Alkyl Halides.” J. Am. Chem. Soc. 2018, 140, 1159-1164.

28) Karunananda, M. K.; Mankad, N. P. “Cooperative Strategies for Catalytic Hydrogenation of Unsaturated Hydrocarbons.” ACS Catalysis 2017, 7, 6110-6119. *Perspective Article

27) Cheng, L.-J.; Mankad, N. P. “Cu-Catalyzed Hydrocarbonylative C-C Coupling of Terminal Alkynes with Alkyl Iodides.” J. Am. Chem. Soc. 2017, 139, 10200-10203. *Highlighted in Organic Chemistry Portal

26) Pye, D. R.; Cheng, L.-J.; Mankad, N. P. “Cu/Mn Bimetallic Catalysis Enables Carbonylative Suzuki-Miyaura Coupling with Unactivated Alkyl Electrophiles.” Chem. Sci. 2017, 8, 4750-4755. *Cover article (cover art by Myrna Romero)

25) Pye, D. R.; Mankad, N. P. “Bimetallic Catalysis for C-C and C-X Coupling Reactions.” Chem. Sci. 2017, 8, 1705-1718. *Perspective Article
*Cover article (cover art by

24) Mazzacano, T. J.; Leon, N. J.; Waldhart, G. W.; Mankad, N. P. “Fundamental organometallic chemistry under bimetallic influence: driving ß-hydride elimination and diverting migratory insertion at Cu and Ni.” Dalton Trans. 2017, 46, 5518-5521. *Special themed issue: Multimetallic complexes: synthesis and applications. *Cover article (cover art by


23) Mazzacano, T. J.; Mankad, N. P. “Dehydrogenative Borylation and Silylation of Styrenes Catalyzed by Copper-Carbenes.” ACS Catal. 2017, 7, 146-149.

22) Johnson, B. J.; Mankad, N. P. “Model Compounds of Copper-Containing Enzymes Involved in Bacterial Denitrification.” In Metalloenzymes in Denitrification : Applications and Environmental Impacts; Moura, I.; Moura, J. J. G.; Pauleta, S. R.; Maia, L. B., Eds.; Royal Society of Chemistry 2016: Cambridge, UK; pp. 225-251. doi: 10.1039/9781782623762-00225. [book link]

21) Waldhart, G. W.; Mankad, N. P.; Santarsiero, B. D. “Improvements to the Practical Usability of the ‘Crystalline Sponge’ Method for Organic Structure Determination.” Org. Lett. 2016, 18, 6112-6115.
*Highlighted in C&E News Science Concentrates

20) Johnson, B. J.; Antholine, W. E.; Lindeman, S. V.; Graham, M. J.; Mankad, N. P. “A One-Hole Cu4S Cluster with N2O Reductase Activity: A Structural and Functional Model for CuZ*.” J. Am. Chem. Soc. 2016, 138, 13107-13110.

19) Karunananda, M. K.; Mankad, N. P. “Heterobimetallic H2 Addition and Alkene/Alkane Elimination Reactions Related to the Mechanism of E-Selective Alkyne Semihydrogenation.” Organometallics 201736, 220–227. *Special Issue: Hydrocarbon Chemistry: Activation and Beyond.

18) Mankad, N. P. “Selectivity Effects in Bimetallic Catalysis.” Chem. Eur. J. 201622, 5822–5829. *Concepts Article (frontispiece by

17) Bagherzadeh, S.; Mankad, N. P. “Extremely Efficient Hydroboration of Ketones and Aldehydes by Copper Carbene Catalysis.” Chem. Commun. 2016, 52, 3844-3846.

16) Karunananda, M. K.; Mankad, N. P. “E-Selective Semi-Hydrogenation of Alkynes by Heterobimetallic Catalysis.” J. Am. Chem. Soc. 2015, 137, 14598-14601.

15) Parmelee, S. R.; Mankad, N. P. “A Data-Intensive Re-Evaluation of Semibridging Carbonyl Ligands.” Dalton Trans. 201544, 17007-17014. *Perspective Article

14) Bagherzadeh, S.; Mankad, N. P. “Catalyst Control of Selectivity in CO2 Reduction Using a Tunable Heterobimetallic Effect.” J. Am. Chem. Soc. 2015, 137, 10898-10901.

13) Karunananda, M. K.; Parmelee, S. R.; Waldhart, G. W.; Mankad, N. P. “Experimental and Computational Characterization of the Transition State for C–X Bimetallic Oxidative Addition at a Cu–Fe Reaction Center.” Organometallics 2015, 34, 3857-3864.

12) Johnson, B. J.; Antholine, W. E.; Lindeman, S. V.; Mankad, N. P. “A Cu4S Model for the Nitrous Oxide Reductase Active Sites Supported Only by Nitrogen Ligands.” Chem. Commun. 2015, 51, 11860-11863.

11) Parmelee, S .R.; Mazzacano, T. J.; Zhu, Y.; Mankad, N. P.; Keith, J. A. “A Heterobimetallic Mechanism for C-H Borylation Elucidated from Experimental and Computational Data.” ACS Catal. 2015, 5, 3689-3699.

10) Waldhart, G. W.; Mankad, N. P. “Photochemical Heck Benzylation of Styrenes Catalyzed by Na[FeCp(CO)2].” J. Organomet. Chem. 2015, 793, 171-174. *Special Issue on Functionalization of CH Bonds with Applications in Catalysis dedicated to Professor Shilov in Memoriam

9) Mazzacano, T. J.; Mankad, N. P. “Thermal C-H borylation using a CO-free iron boryl complex.” Chem. Commun. 201551, 5379-5382. *ChemComm Emerging Investigators Issue 2015

8) Banerjee, S.; Karunananda, M. K.; Bagherzadeh, S.; Jayarathne, U.; Parmelee, S. R.; Waldhart, G. W.; Mankad, N. P. “Synthesis and Characterization of Heterobimetallic Complexes with Direct Cu–M Bonds (M = Cr, Mn, Co, Mo, Ru, W) Supported by N-Heterocyclic Carbene Ligands: A Toolkit for Catalytic Reaction Discovery.” Inorg. Chem. 201453, 11307-11315.

7) Johnson, B. J.; Lindeman, S. V.; Mankad, N. P. “Assembly, Structure, and Reactivity of Cu4S and Cu3S Models for the Nitrous Oxide Reductase Active Site, CuZ*.” Inorg. Chem. 201453, 10611-10619.

6) Karunananda, M. K.; Vazquez, F. X.; Alp, E. E.; Bi, W.; Chattopadhyay, S.; Shibata, T.; Mankad, N. P. “Experimental Determination of Redox Cooperativity and Electronic Structure in Catalytically Active Cu-Fe and Zn-Fe Heterobimetallic Complexes.” Dalton Trans. 201443, 13361-3671.

5) Jayarathne, U.; Parmelee, S. R.; Mankad, N. P. “Small Molecule Activation Chemistry of Cu-Fe Heterobimetallic Complexes Toward CS2 and N2O.” Inorg. Chem. 201453, 7730-7737.

4) Mankad, N. P. “Non-Precious Metal Catalysts for C–H Borylation Enabled by Metal-Metal Cooperativity.” Synlett 201425, 1197-1201. *SYNPACTS articlei_p1117_ga_10-1055_s-0033-1340823

3) Waldhart, G. W.; Mankad, N. P. “trans-Tetracarbonylbis(triphenylphosphane-kP)molybdenum(0).” Acta Cryst. 2014E70, m35.

2) Mazzacano, T. J.; Mankad, N. P. “Base Metal Catalysts for Photochemical C-H Borylation That Utilize Metal-Metal Cooperativity.” J. Am. Chem. Soc. 2013135, 17258-17261.
*Cover article (cover art by Myrna Romero)
*Highlighted in JACS SpotlightsUIC NewsScienceDailyChemical Processing
1) Jayarathne, U.; Mazzacano, T. J.; Bagherzadeh, S.; Mankad, N. P. “Heterobimetallic Complexes with Polar, Unsupported Cu-Fe and Zn-Fe Bonds Stabilized by N-Heterocyclic Carbenes.” Organometallics 201332, 3986-3992.

Supervised Publications

19) Johnson, M. W.; Bagley, S. W.; Mankad, N. P.; Bergman, R. G.; Mascitti, V.; Toste, F. D. “Application of Fundamental Organometallic Chemistry to the Development of Gold-Catalyzed Synthesis of Sulfinate Derivatives.” Angew. Chem., Int. Ed. 201453, 4404-4407.
18) Mankad, N. P.; Toste, F. D. “C(sp3)-F Reductive Elimination from Alkylgold(III) Complexes.” Chem. Sci. 20123, 72-76.
17) Tkatchouk, E.; Mankad, N. P.; Benitez, D.; Goddard, W. A., III; Toste, F. D. “Two Metals Are Better Than One in the Gold Catalyzed Oxidative Heteroarylation of Alkenes.” J. Am. Chem. Soc. 2011133, 14293-14300.
16) Takaoka, A.; Mankad, N. P.; Peters, J. C. “Dinitrogen Complexes of Sulfur-Ligated Iron. J. Am. Chem. Soc. 2011, 133, 8440-8443.
15) Tsay, C.; Mankad, N. P.; Peters, J. C. “Four-coordinate, trigonal pyramidal Pt(II) and Pd(II) complexes.” J. Am. Chem. Soc. 2010132, 13975-13977.
14) Mankad, N. P.; Toste, F. D. “C-C Coupling Reactivity of an Alkylgold(III) Fluoride Complex with Arylboronic Acids.” J. Am. Chem. Soc. 2010132, 12859-12861.
13) Lee, Y.; Mankad, N. P.; Peters, J. C. “Triggering N2 uptake via redox-induced expulsion of coordinated NH3 and N2 silylation at trigonal bipyramidal iron.” Nature Chem. 20102, 558-565.
12) Mankad, N. P.; Müller, P.; Peters, J. C. “Catalytic N-N Coupling of Aryl Azides to Yield Azoarenes via Trigonal Bipyramidal Iron-Nitrene Intermediates.” J. Am. Chem. Soc. 2010132, 4083-4085.
11) Mankad, N. P.; Harkins, S. B.; Antholine, W. E.; Peters, J. C. “Multifrequency EPR Studies of [Cu1.5Cu1.5]+ for Cu2(µ-NR2)2 and Cu2(µ-PR2)2 Diamond Cores.” Inorg. Chem. 200948, 7026-7032.
10) Mankad, N. P.; Antholine, W. E.; Szilagyi, R. K.; Peters, J. C. “Three-Coordinate Copper(I) Amido and Aminyl Radical Complexes. J. Am. Chem. Soc. 2009, 131, 3878-3880.
9) Whited, M. T.; Mankad, N. P.; Lee, Y.; Oblad, P. F.; Peters, J. C. “Dinitrogen complexes supported by tris(phosphino)silyl ligands. Inorg. Chem. 200948, 2507-2517.
8) Harkins, S. B.; Mankad, N. P.; Miller, A. J. M.; Szilagyi, R. K.; Peters, J. C. “Probing the Electronic Structures of [Cu2(µ-XR2)2]n+ Diamond Cores as a Function of the Bridging X atom (X = N or P) and Charge (n = 0, 1, 2).” J. Am. Chem. Soc. 2008130, 3478-3485.
7) Mankad, N. P.; Peters, J. C. “Diazoalkanes react with a bis(phosphino)borate copper(I) source to generate [Ph2BPtBu2]Cu(η1-N2CR2), [Ph2BPtBu2]Cu(CPh2), and [Ph2BPtBu2]Cu-N(CPh2)(NCPh2).” Chem. Commun. 2008, 1061-1063.
6) Mankad, N. P.; Whited, M. T.; Peters, J. C. “Terminal FeI-N2 and FeII···H-C Interactions Supported by Tris(phosphino)silyl ligands.” Angew. Chem., Int. Ed. 200746, 5768-5771.
5) Thomas, C. M.; Mankad, N. P.; Peters, J. C. “Characterization of the Terminal Iron(IV) Imides {[PhBPtBu2(pz’)]FeIV≣NAd}+.” J. Am. Chem. Soc. 2006128, 4956-4957.
4) Mankad, N. P.; Rivard, E.; Harkins, S. B.; Peters, J. C. “Structural Snapshots of a Flexible Cu2P2 Core that Accommodates the Oxidation States CuICuI, Cu1.5Cu1.5, CuIICuII.” J. Am. Chem. Soc. 2005127, 16032-16033.
3) Rieth, R. D.; Mankad, N. P.; Calimano, E.; Sadighi, J. P. “Palladium-catalyzed cross-coupling of pyrrole anions with aryl chlorides, bromides, and iodides.” Org. Lett. 20046, 3981-3983.
2) Mankad, N. P.; Laitar, D. S.; Sadighi, J. P. “Synthesis, Structure, and Alkyne Reactivity of a Dimeric (Carbene)copper(I) Hydride.” Organometallics 200423, 3369-3371.
1) Mankad, N. P.; Gray, T. G.; Laitar, D. S.; Sadighi, J. P. “Synthesis, Structure, and CO2 Reactivity of a Two-Coordinate (Carbene)copper(I) Methyl Complex.” Organometallics 200423, 1191-1193.